LookMeds vs. Sesame for GLP-1 Medications

Not all weight-loss programs are created equal; find out how LookMeds and Sesame compare.

Glucagon-like peptide-1 (GLP-1) medications, which are primarily used for type 2 diabetes and blood sugar level control, have transformed the landscape of body weight loss drugs. However, side effects must be taken into consideration. As demand grows, more companies are offering access to these powerful treatments. But not all weight loss programs are created equal.

LookMeds and Sesame both offer prescription weight-loss and obesity management medications, such as semaglutide and tirzepatide; however, they differ in terms of price, medication selection, care model, and long-term support. Whether you're looking for flexibility, affordability, or hands-on coaching, understanding how these two providers compare can help you make the right decision.

In this guide, we’ll break down the key differences between LookMeds and Sesame to help you choose the program that aligns best with your goals.

  • LookMeds offers personalized care with continuous support, including regular check-ins and dosage adjustments at no additional cost, ensuring a tailored weight loss journey with both injectable and tablet options.
  • Sesame provides a broader range of chronic weight management meds, including popular brand-name options like Ozempic and Wegovy, along with compounded semaglutide, giving you greater flexibility in choosing a treatment plan.
  • LookMeds offers a 100% satisfaction guarantee within the first 30 days, giving you peace of mind and the ability to try the service risk-free.
  • Sesame offers competitive pricing, with compounded semaglutide starting at $249 per month, giving you an affordable option for weight loss treatments.

How LookMeds Compares to Sesame

Both LookMeds and Sesame offer access to prescription weight loss treatments, but their approaches to care, medication selection, and patient support differ significantly.

LookMeds focuses on personalized treatment through compounded GLP-1 drugs—specifically semaglutide and tirzepatide—available in both tablets and injections. The program is designed for convenience and consistency, offering built-in telehealth, regular progress check-ins, and free dosage adjustments throughout the journey.

Sesame, meanwhile, combines access to popular brand-name options, like Ozempic, Wegovy, Zepbound, and Mounjaro, with a broader emphasis on long-term lifestyle change. Their plans are structured to support sustainable weight loss by integrating behavioral coaching with clinical care.

While both providers offer GLP-1 medications, the choice between them often comes down to whether you prefer a more structured medical coaching model (Sesame) or a more streamlined, medication-focused approach (LookMeds).

LookMeds Methodology: LookMeds helps patients achieve sustainable weight loss by providing scientifically proven support through GLP-1 receptor agonists, compounded in certified, state-licensed compounding pharmacies, and guidance from licensed healthcare professionals and nutrition experts.

Sesame Methodology: Sesame offers personalized weight loss plans with various medications, including compounded semaglutide, Zepbound, Zepbound vial, Wegovy, Ozempic, Mounjaro, Saxenda, and Victoza. They offer close clinical supervision focused on sustainable, long-term changes to diet, exercise, and behavior.

In the following sections, we compare LookMeds and Sesame to help you determine which option might best fit your weight loss goals.

Compare LookMeds vs. Sesame Side-By-Side

Choosing the right weight loss program goes beyond just access to GLP-1 medications—it’s also about how treatments are delivered, the support you receive, and the overall value for your investment.

LookMeds and Sesame both offer effective prescription options, including compounded semaglutide. However, they differ in important ways, from medication variety and pricing to clinical care models and cancellation policies.

By laying out these differences side-by-side, you’ll have a clearer view of which provider better fits your personal goals, preferences, and long-term weight loss needs.

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How the Process Works for Each Provider

Starting your weight loss journey begins with selecting a provider who aligns with your goals and expectations. Now that you’ve seen how LookMeds and Sesame compare in terms of pricing, medication access, and clinical support, it’s time to look at what happens next.

Here’s how you can get started with each platform:

How It Works at LookMeds

  1. Complete an Assessment: LookMeds asks questions about your health, lifestyle, and weight loss goals to assess eligibility. If you qualify, you’ll then complete a more detailed assessment, which will allow a medical professional to determine your prescription.
  2. Receive a Prescription: After, LookMeds sends a personalized GLP-1 prescription, which will arrive at your door within 1-3 days in discreet packaging. 
  3. Begin Treatment: Each delivery will include all necessary supplies and clear instructions for storing and administering the compounded medications.
  4. Monitor Progress: During your treatment, you’ll have regular check-ins to track progress and adjust the dosage, all at no extra cost.

How It Works at Sesame

  1. Complete a Quick Questionnaire: Start by answering a few questions about your weight loss history and goals to help personalize your treatment plan. Then, choose your Sesame provider.
  2. Meet Your Provider: Connect with your healthcare provider via video consultation to discuss your health conditions, medical history, and goals. They may order lab tests if metabolic data is needed.
  3. Start Your Treatment: If appropriate, your provider will prescribe a personalized weight loss medication. Sesame will deliver it to your door or your preferred pharmacy.
  4. Stay Supported: Get ongoing support through unlimited messaging with your provider and follow-up visits to monitor your progress and adjust your treatment as needed.

Who Is Each Provider Best for?

When choosing between LookMeds and Sesame, consider these key highlights.

Choose LookMeds if you want…

  • A simplified, medication-first approach with compounded semaglutide or tirzepatide in either tablet or injection form.
  • Consistent pricing that doesn’t change with dose adjustments, plus free telehealth check-ins to track progress.
  • A satisfaction guarantee with the option to cancel anytime and get a refund within the first 30 days.

Choose Sesame if you want…

  • Access to a wider range of brand-name weight loss medications like Ozempic, Wegovy, Zepbound, and more.
  • Structured clinical guidance focused on long-term behavioral change alongside medical treatment.
  • Flexible plans starting as low as $89/month if you're filling prescriptions at your own pharmacy.

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Bottom Line

Both LookMeds and Sesame offer effective GLP-1-based weight loss solutions, but they cater to different needs. If you’re looking for a streamlined, affordable program with compounded medications and ongoing care built into one flat monthly fee, LookMeds is a great fit.

On the other hand, if you prefer access to name-brand medications and a more hands-on coaching model that emphasizes long-term lifestyle changes, Sesame may be the better choice. Ultimately, the right provider depends on your personal preferences, goals, and how much support you want along the way.

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